Multiparametric assays & bioinformatics for consistency testing
The objectives of this work package are:
- to develop transcriptomics/proteomics technology and identify bacterial biomarkers suitable for characterization of Clostridium tetani seed strains,
- to develop an alternative for the histamine sensitisation test for Pertussis vaccine safety based on kinome analysis and
- to develop platform technology and identify biomarkers for the assessment of vaccine quality based on responses of antigen presenting cells to exposure to vaccines/adjuvants in vitro, in support to Work Package 3
Partners involved
- National Institute for Public Health and the Environment (RIVM)
- University of Utrecht (UU)
- University Medical Center Groningen (UMCG, Work Package Leader)
- Institute for Translational Vaccinology (Intravacc)
- University of Applied Sciences (HU)
- Scientific Institute of Public Health (WIV-ISP)
- Sanofi Pasteur (SP)
- Zoetis
- Merial
- Boehringer Ingelheim (BI)
- Merck Sharp & Dohme (MSD)
- GlaxoSmithKline (GSKBio)