Multiparametric assays & bioinformatics for consistency testing

The objectives of this work package are:

• to develop transcriptomics/proteomics technology and identify bacterial biomarkers suitable for characterization of Clostridium tetani seed strains,
• to develop an alternative for the histamine sensitisation test for Pertussis vaccine safety based on kinome analysis and
• to develop platform technology and identify biomarkers for the assessment of vaccine quality based on responses of antigen presenting cells to exposure to vaccines/adjuvants in vitro, in support to Work Package 3

Partners involved

• National Institute for Public Health and the Environment (RIVM)
• University of Utrecht (UU)
• University Medical Center Groningen (UMCG, Work Package Leader)
• Institute for Translational Vaccinology (Intravacc)
• University of Applied Sciences (HU)
• Scientific Institute of Public Health (WIV-ISP)
• Sanofi Pasteur (SP)
• Zoetis
• Merial
• Boehringer Ingelheim (BI)
• Merck Sharp & Dohme (MSD)
• GlaxoSmithKline (GSKBio)